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Changes in Helicobacter pylori-induced gastritis in the antrum and corpus during long-term acid-suppressive treatment in Japan.

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US multicenter, double-blind, placebo-controlled study of Pantoprazole 10 mg, 20 mg, or 40 mg once daily was conducted in 603 patients with reflux symptoms and endoscopically diagnosed EE of grade 2 or above (Hetzel-Dent scale).

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Hypomagnesemia resolved within 1 week (median) following discontinuance and recurred within 2 weeks (median) of rechallenge.

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Pantoprazole sodium, used as a starting material for the preparation of pantoprazole sodium sesquihydrate in the first aspect of the invention, can also be obtained by the methods described in the second and third aspect of the present invention.

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The process suffers from the drawback that methoxylation of the intermediate of Formula II may lead to formation of undesired side-product, formed by the methoxylation at nitrogen linked to hydrogen of the benzimidazole ring, due to which additional chromatographic purification steps are needed and the yields obtained are low.

The patient was then able to eat regular meals with no ill effects.

Despite this consistent evidence, there are substantial recurrence rates further along the treatment course of these patients.

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The use and subsequent withdrawal of PPIs may be associated with an exaggeration of, or new onset of, acid-related symptoms.

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However, PPIs do not improve clinical outcomes such as further bleeding, surgery, or death (Conditional recommendation).

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