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Correction of hypokalemia and any coexisting hypomagnesmia is recommended prior to the initiation of thiazides.

Patients in the Prospective Randomized Amlodipine Survival Evaluation (PRAISE) Study were classified as having “nonischemic dilated cardiomyopathy” on the basis of a coronary angiogram if available, a history of angina, or a previous myocardial infarction, although the numbers of patients classified according to each of these criteria are not provided.

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In the Reduction in Endpoints in Patients with non-Insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan (RENAAL) trial, losartan (plus conventional antihypertensive therapy, including calcium channel blockers) was shown to be superior to placebo (plus conventional antihypertensive therapy, including calcium channel blockers) in type II diabetics with nephropathy in preventing the composite end point of end-stage renal disease, doubling of serum creatinine, or death.

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Coadministration of 240 mL of grapefruit juice with a single oral dose of amlodipine 10 mg in 20 healthy volunteers had no significant effect on the pharmacokinetics of amlodipine.

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