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Approved in 2005 for adults with moderate-to-severe RA who have not responded to DMARD or anti-TNF drugs.

SIGN Guideline 48 ( 2002) Management of early rheumatoid arthritis.

Rarely, this medication can cause serious, even fatal, side effects such as a severe peeling skin rash known as Stevens- Johnson syndrome, blood disorders (e.

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Safe administration of DMARDs requires critical and careful monitoring ( Table 3 Guidelines for Monitoring the Treatment of Rheumatoid Arthritis.

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