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enter site What is the strongest antibiotic for sinus infection? Amoxicillin (Amoxil) is acceptable for uncomplicated acute sinus infections ; however, many doctors prescribe amoxicillin -clavulanate (Augmentin) as the first-line antibiotic to treat a possible bacterial infection of the sinuses. Amoxicillin usually is effective against most of the strains of bacteria.
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